oxidative stress and neurodegenerative disorders pdf

Oxidative Stress And Neurodegenerative Disorders Pdf

On Wednesday, December 23, 2020 10:17:02 AM

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A growing body of evidence suggests the alteration of the reduction-oxidation redox homeostasis in the brain grown with the increasing of the age. These neurodegenerative disorders are typically characterized by the progressive loss of neuronal cells and compromised motor or cognitive functions. It has been shown that neuronal cells are particularly vulnerable to oxidative damage due to their high polyunsaturated fatty acid content in membranes, high oxygen consumption, and weak antioxidant defence.

Oxidative Stress, Antioxidants and Neurodegenerative Diseases

DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. Researchers, clinicians and students in the fields of neuroscience, neurology, biochemistry and drug discovery who are interested in neurodegenerative disorders. Allan Butterfield.

Oxidative Stress and Neurodegenerative Disorders

Perspective Free access Address correspondence to: Susan L. Phone: ; Fax: ; E-mail: sla jax. Find articles by Klein, J. Find articles by Ackerman, S. Published March 15, - More info. While numerous studies have examined the existence of increased reactive oxygen species ROS in later-onset neurodegenerative disorders, the mechanism by which neurons die under conditions of oxidative stress remains largely unknown.

Introduction: The incidence and prevalence of neurodegenerative diseases increase with life expectancy. Brain, for physiological and biochemical reasons, has a high sensitivity to oxidative stress. Therefore, maintaining the redox homeostasis is essential for brain cells. In addition, brain antioxidant levels are limited compared to other tissues. In this article, different mechanisms involved in the production of endogenous and exogenous reactive oxygen species and the role of oxidative stress in neurodegenerative diseases were discussed.


Thus, oxidative stress elicits various neurodegenerative diseases. In addition, chemotherapy could result in severe side effects on the CNS and.


Apoptosis and Oxidative Stress in Neurodegenerative Diseases

It is edited by Dr. The Journal accepts works on basic as well applied research on any field of neurology. The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two receding years.

Author contributions: Xueping Chen is responsible for designing and writing the manuscript. Chunyan Guo helps to revise the manuscript. Jiming Kong is responsible for manuscript oversight and instruction. The mitochondrial respiratory chain and enzymatic reactions by various enzymes are endogenous sources of reactive oxygen species.

Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading to neuro-degeneration. Neural cells suffer functional or sensory loss in neurodegenerative diseases. Apart from several other environmental or genetic factors, oxidative stress OS leading to free radical attack on neural cells contributes calamitous role to neuro-degeneration.

Oxidative stress and neurodegenerative disorders

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